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Epidemiological study on Diet and Breast Cancer:

Categories: Articles, Western Medicine

Meta-analyses of lignans and enterolignans in relation to breast cancer risk.

RESULTS: We included 21 studies (11 prospective cohort studies and 10
case-control studies) in the meta-analyses. Lignan exposure was not
associated with an overall breast cancer risk (RE: 0.92; 95% CI: 0.81,
1.02; P(heterogeneity) = 0.004). However, in postmenopausal women, high
lignan intake was associated with a significant reduced risk of breast
cancer (13 studies; RE: 0.86; 95% CI: 0.78, 0.94; P(heterogeneity) =
0.32). Breast cancer risk was also inversely associated with
enterolignan exposure (4 studies; RE: 0.84; 95% CI: 0.71, 0.97) but not
with blood or urine enterolactone concentrations. The associations were
not significantly different between ER-status subgroups (6 studies).
CONCLUSIONS: High lignan exposure may be associated with a reduced
breast cancer risk in postmenopausal women. Additional work is
warranted to clarify the association between lignan exposure and breast
cancer risk.

Lignans and food sources of them (rated)

Broccoli could aid breast cancer fight

Categories: Articles, Western Medicine

Broccoli could aid breast cancer fight

Submitted by Drew Kaplan


The vegetable, already hailed as a so-called “superfood”, contains a chemical capable of targeting the cells which fuel the growth of tumours.  A component of broccoli called sulforaphane targets and kills cancer stem cells as well as preventing new tumours from growing, according to
researchers at the University of Michigan. Current chemotherapies do not work against cancer stem cells.  Researchers believe that eliminating the cancer stem cells is key to
controlling cancer.

The study, published in the journal Clinical Cancer Research, charts how scientists at the university’s Comprehensive Cancer Centre tested the effects of sulforaphane in experiments involving mice and cell cultures.

Prof Duxin Sun, the author of the study, said:  “Sulforaphane has been studied previously for its effects on cancer, but this study shows that its benefit is in inhibiting the breast cancer stem cells. This new insight suggests the potential of sulforaphane or broccoli extract to prevent or treat cancer by targeting the critical cancer stem cells.”

Researchers took mice with breast cancer and injected varying concentrations of sulforaphane from the broccoli extract.  They then used several established methods to assess the number of cancer stem cells in the tumours.

These measures showed a marked decrease in the cancer stem cell population after treatment with sulforaphane, with little effect on the normal cells.

Cancer cells from mice treated with sulforaphane were also unable to generate new tumours.

The researchers then tested sulforaphane on human breast cancer cell cultures in the lab, finding similar decreases in the cancer stem cells.  Researchers are currently developing a method to extract and preserve sulforaphane.  The tests involved higher concentrations of sulforaphane than are available by simply eating broccoli.