Epidemiological study on Diet and Breast Cancer:

Categories: Articles, Western Medicine

Meta-analyses of lignans and enterolignans in relation to breast cancer risk.

RESULTS: We included 21 studies (11 prospective cohort studies and 10
case-control studies) in the meta-analyses. Lignan exposure was not
associated with an overall breast cancer risk (RE: 0.92; 95% CI: 0.81,
1.02; P(heterogeneity) = 0.004). However, in postmenopausal women, high
lignan intake was associated with a significant reduced risk of breast
cancer (13 studies; RE: 0.86; 95% CI: 0.78, 0.94; P(heterogeneity) =
0.32). Breast cancer risk was also inversely associated with
enterolignan exposure (4 studies; RE: 0.84; 95% CI: 0.71, 0.97) but not
with blood or urine enterolactone concentrations. The associations were
not significantly different between ER-status subgroups (6 studies).
CONCLUSIONS: High lignan exposure may be associated with a reduced
breast cancer risk in postmenopausal women. Additional work is
warranted to clarify the association between lignan exposure and breast
cancer risk.

Lignans and food sources of them (rated)